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Prolonged telomeres: acne can prevent the skin from aging

Prolonged telomeres: acne can prevent the skin from aging


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Acne causes the skin to age more slowly
Pimples and blackheads are common among adolescents during puberty. Blemished skin is usually a major burden for them. But British acne apparently also has advantages in the form of longer telomeres, reports. This better protects the cells against aging.

Pimples are widespread in adolescents
Skin problems in teenagers are quite normal. In order to find out what really helps against pimples, it makes sense to know what causes them. It is known that factors such as stress or poor nutrition are possible causes. In many cases, simple home remedies for pimples are enough. Otherwise, purulent pimples should not be expressed. Despite the adversity, acne apparently also has advantages, as British researchers now report.

Telomeres protect the cells during replication
Scientists from Kings College London found that people who previously had acne have longer telomeres. These protect your cells significantly better against aging. The doctors released a press release on the results of their study.

The authors explain that telomeres are so-called repetitive nucleotide sequences at the end of the chromosomes. These telomeres protect the cells during the replication process. As the cells get older, the telomeres shrink and break. Eventually this will eventually trigger cell death, a normal part of human growth and aging, doctors add.

Researchers study telomeres from 1,295 twins
Previous studies have already shown that the telomere length in white blood cells can be predictive for biological age, the experts explain. For this reason, the new study attempted to determine the length of white blood cell telomeres in 1,295 twins. A quarter of the twins from the so-called TwinsUK cohort reported experiences with acne in their lives.

Longer telomeres provide better protection
Statistical analyzes showed that the telomere length was significantly longer in people with acne. This better protects white blood cells from the usual deterioration caused by age, the researchers explain. One of the genes involved in telomere length was also associated with the appearance of acne.

Dermatologists have long indicated that the skin of people with acne seems to age more slowly than the skin of people without a history of acne. Signs of aging, such as wrinkles and skin thinning, often appeared much later in people with previous acne, the scientists explain.

Acne affects the so-called gene pathway p53
The researchers also examined gene expression in existing skin biopsies in twins. It was found that a so-called gene pathway (p53 pathway) regulates the programmed death of cells, the experts say. This seems to be less common in people with acne. This finding requires further investigation of other genes to identify their involvement in cell aging. The authors also analyzed how these genes differ from those in people with acne.

More research is needed
The results of the study suggest that the cause of slower cell aging is linked to the length of the telomeres, the doctors say. This seems to be different in people with acne. Using the skin biopsies, the scientists were able to determine the gene expressions in connection with the telomere length. Of course, further research is needed to check whether the gene pathways form the basis for a useful intervention. Longer telomeres still seem to be a factor that protects the skin from premature aging, explains Dr. Bataille. (as, ad)

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